What Are the Best Non-Stimulant ADHD Medications for Adults?

Explore the best non-stimulant ADHD medication options for adults, their benefits, and side effects to find the right ADHD treatment.

Adult ADHD can impact focus, memory, organization, and emotional regulation. While stimulant medication is often the first-line ADHD treatment, it isn’t always the best fit for everyone. Some adults experience intolerable side effects, have a history of substance misuse, or simply don’t respond well to stimulant drugs. That’s where non-stimulant ADHD medication comes in. Read on to learn more about commonly-prescribed non-stimulant ADHD medication and other forms of treatment for managing ADHD.

Why choose non-stimulant medications?

Non-stimulant medications can be effective in reducing ADHD symptoms without the risks of dependency associated with stimulant drugs. For adults, these alternatives may be preferred when:

• Stimulant medication worsens anxiety, insomnia, or mood changes
• There is a medical condition that makes stimulant drugs unsafe
• A person has experienced misuse or dependency to stimulant medication

Every individual’s ADHD symptoms and health history are unique. For some, stimulant medication remains the most effective choice. For others, non-stimulant ADHD medication provides a safer, more sustainable treatment path. A personalized plan, often combining medication with therapy and lifestyle changes, gives the best chance for long-term success.

Types of non-stimulant ADHD medication

Here’s an overview of some common types of non-stimulant ADHD medications — and the common side effects of each.

1. Atomoxetine (Strattera)

Atomoxetine is an FDA-approved non-stimulant medication that targets norepinephrine, a neurotransmitter involved in attention and impulse control. It’s often considered one of the best options for adults who cannot take stimulant medicine.

Common side effects: dry mouth, insomnia, decreased appetite, and nausea.

2. Guanfacine (Intuniv)

Originally developed for high blood pressure, Guanfacine is sometimes prescribed as an ADHD medicine. It can improve attention and impulse control, especially in adults with coexisting anxiety.

Common side effects: sleepiness, dizziness, and low blood pressure.

3. Clonidine (Kapvay)

Similar to Guanfacine, Clonidine is another non-stimulant option used for ADHD treatment. It may be especially helpful for hyperactivity and impulsivity, as well as for adults who struggle with sleep issues.

Common side effects: drowsiness, dry mouth, and fatigue.

4. Bupropion (Wellbutrin)

Though not FDA-approved specifically for ADHD, Bupropion is an antidepressant that is often prescribed off-label as a nonstimulant medication. It helps regulate dopamine and norepinephrine, improving focus and motivation.

Common side effects: headache, insomnia, and weight changes.

Like all ADHD medicines, non-stimulant medications carry benefits and potential drawbacks. Some adults notice a slower onset of symptom relief compared to stimulant drugs, but they often experience fewer risks of misuse or dependency. Monitoring and regular check-ins with a healthcare provider are essential to finding the right balance.

Therapy and support options for adult ADHD

Medication can significantly reduce symptoms, but many adults benefit from combining it with therapy and behavioral strategies. ADHD treatment is most effective when it addresses both the biological and practical challenges of living with the condition.

Working with a licensed ADHD therapist or psychologist provides structured support for managing organization, time management, and emotional regulation. Cognitive-behavioral therapy (CBT) is particularly effective for ADHD, as it targets unhelpful thought patterns and builds practical coping strategies.

Virtual therapy platforms make ADHD treatment more accessible, especially for adults with busy schedules. Online sessions can include coaching, CBT, and group therapy for ADHD students, parents, or professionals managing symptoms.

Outside of therapy, people can also pursue coaching and skills training for ADHD support. ADHD coaches help adults develop personalized systems for organization, reducing distraction, and setting achievable goals. Also, lifestyle approaches like exercise, mindfulness practices, sleep regulation, and nutrition adjustments can support symptom management and improve mental health.

How Charlie Health can help

If you or a loved one is struggling with your mental health and could use more than once-weekly support, Charlie Health is here to help. Charlie Health’s virtual Intensive Outpatient Program (IOP) provides behavioral health treatment for people dealing with serious mental health conditions, including ADHD. Our expert clinicians incorporate evidence-based therapies into individual counseling, family therapy, and group sessions. We also offer medication management, as needed. With this kind of holistic online treatment, managing your mental health is possible. Fill out the form below or give us a call to start healing today.